Injection Therapy · Patient Education · 7 min read
TriMix Titration Guide
The goal of TriMix therapy is an erection firm enough for satisfactory sexual activity while minimizing the risk of prolonged erections and other side effects. The ideal erection lasts approximately 30 to 60 minutes and resolves completely without intervention.
How to Titrate
Begin with the starting dose recommended by your prescribing provider. If the response is inadequate, increase the dose gradually with each subsequent injection until the lowest effective dose is identified.
- Increase by 2 to 5 units (0.02 to 0.05 mL) at a time
- Wait at least 24 hours between injections
- Do not increase the dose more frequently than directed by your provider
Example Titration Schedule
Continue increasing gradually until satisfactory rigidity is achieved.
Frequency Limits
- No more than one injection within a 24-hour period
- No more than three injections per week
- Alternate sides of the penis with each injection
- Store TriMix refrigerated, and discard it after the period your pharmacy specifies (often about 30 days)
Reading Your Response
Ideal Response
- Firm enough for penetration
- Begins working within 5 to 20 minutes
- Lasts approximately 30 to 60 minutes
- Resolves completely on its own
Signs Too Low
- Partial erection only
- Inadequate rigidity for intercourse
- Erection loses firmness quickly
Signs Too High
- Erection persists beyond 2 hours
- Significant penile discomfort
- Excessive bruising or swelling
Priapism (Prolonged Erection) Action Plan
More than 2 hours
Consider taking pseudoephedrine if approved by your physician.
More than 3 hours
Contact your urology provider immediately.
4 hours or longer
Proceed to the nearest emergency department immediately. This is a urologic emergency.
Injection Technique Reminders
- Inject at the 10 o'clock OR 2 o'clock position on the side of the penile shaft
- NEVER inject at the 12 o'clock position — the nerves, arteries, and veins (the dorsal neurovascular bundle) run there
- NEVER inject at the 6 o'clock position — the urethra runs along the underside there
- Use a fine 29- or 30-gauge insulin syringe, inserted at a 90° angle. Avoid any visible veins.
- Apply gentle pressure to the injection site for 2 to 3 minutes after injecting
- Record your dose and response to assist with future adjustments
This guide is for educational purposes only and does not replace the specific instructions provided by your prescribing healthcare professional.